Kathleen Maguire (September 27, 1925 – August 9, 1989) was an American actress who won an Obie Award in 1958 for her performance in the stage play, The Time of the Cuckoo.

Born in New York City, Maguire was an acting student of Lee Strasberg and Sanford Meisner.

Maguire was also known for two roles in two short-lived soap operas on television, first as wealthy widow, Kate Austen on A Flame in the Wind; and as extremely conservative doctor's wife, Adrian Sims on the series A World Apart. She later replaced Doris Belack in the role of Anna Wolek Craig in the long-running serial One Life to Live. Among her film credits are the 1957 drama Edge of the City, Flipper (1963), The Borgia Stick (1967), The Concorde ... Airport '79 (1979), Willie & Phil (1980), and the TV movie Bill (1981).