Isaac Hernández was born in Guadalajara, Mexico, one of 11 children of Hector Hernández.

Trained at Philadelphia's The Rock School for Dance Education, he has worked as a professional ballet dancer at the American Ballet Theatre, San Francisco Ballet, Dutch National Ballet and the English National Ballet where he is currently (2018) Lead Principal Dancer.

Apart from his dance career, he has also become an icon for the arts and culture in Mexico, promoting them as a force for social cohesion and progress through free cultural events, workshops and his non-profit organization Releve A.C.

He is also an ambassador for the brands Montblanc, citibank and Maestro Dobel.