Noni Stapleton was born in Cork, Ireland. She trained at The Gaiety School of Acting in Dublin, and is an Irish Theatre Institute, Six in the Attic alumnus.

beginning her theatre career in What The Dead Want (directed by Jimmy Fay) at Project Arts Centre, Dublin. She has continued to work in theatre, TV and film as an actress and writer and has also performed in many Irish-language productions. Noni co-founded Skipalong Theatre Company for which she co-wrote One for Sorrow and Two for a Girl. She is known for Obituary (2023), Penny Dreadful (2014) and Harry Wild (2022).