Tyler Christopher began his acting career on the daytime drama General Hospital as Nikolas Cassadine in July 1996. He immediately captured the hearts of fans and the notice of television critics. He won the Soap Opera Digest Award as "Best Newcomer" in 1997. His first run on the show was from 1996 to 1999. Christopher returned to the show in 2003. He was nominated for a Daytime Emmy Award for Best Younger Actor in 1998 and Best Supporting Actor in 2005 and 2006.

During his hiatus from General Hospital, Christopher was cast as a regular (Ethan) on The Pretender and the two subsequent Pretender TV Movies. He landed the lead role in the CBS Pilot "Sam's Circus" and also the UPN Pilot "One for the Money". In 2006 he was cast in the ABC pilot "Secrets of a Small Town". Tyler made numerous guestappearances on Charmed and Angel, CSI: Las Vegas, Boomtown, JAG, and many more.

Tyler appeared as Jacob Wheeler Jr. in Emmy winning Steven Spielberg's television mini-series Into the West which premiered on June 10, 2005.

Christopher starred in several independent features during his post-GH career: Out of the Black, Catfish in Black Bean Sauce, and Face The Music. All three are available on DVD.

Tyler returned to the role of Nikolas Cassadine on General Hospital in April 2003 and ended his final run as Nikolas Cassadine in July 2016 wit a Daytime Emmy Award. In August 2017, it was announced that Christopher had joined the cast of Days of Our Lives, originating the role of Stefan DiMera. His last episode was March 20, 2019. On October 31, 2023, Tyler Christopher was found dead from positional asphyxia due to acute alcohol intoxication. He was 50 years old.