Shoshannah Stern is an American actress and writer. She was born in Walnut Creek, California, into an observant Jewish and fourth-generation deaf family, the daughter of Ron Stern and Hedy Marilyn Stern (née Udkovich), and the sister of writer and artist Louise Stern and former Gallaudet Men's Basketball Coach and current political scientist Brendan Stern. Both of her grandmothers are Holocaust survivors. Her hometown is Fremont, California, where she attended the California School for the Deaf, Fremont.

Stern's first language is American Sign Language. She is also able to read lips and speak English without an interpreter. She attended Gallaudet University, the only liberal arts college for the deaf in the world. She married her husband, Ricky Mitchell, on June 3, 2012, in Santa Fe, New Mexico. Their daughter was born in February 2015. She currently resides with him in Hollywood, California.

Stern got her first regular series role as Holly Brodeen, a member of an elite government anti-terrorist task force in ABC's Threat Matrix. The role was created for her by the show's producers after a director who had worked with her on The Division recommended her. She had a recurring role as Megan Beals-Botwin in Showtime's Weeds and was also on ER, Providence, and Cold Case. She played Bonnie Richmond in the CBS post-apocalyptic drama Jericho, Eileen Leahy on the CW show Supernatural, and had a recurring role in Fox's Lie to Me. Her 2020 role on Grey's Anatomy is the first recurring deaf doctor role on a prime time television network show.

In 2025, Stern made her directorial debut with Marlee Matlin: Not Alone Anymore, a documentary revolving around actress Marlee Matlin, which will have its world premiere at the 2025 Sundance Film Festival.