She started her studies in the village of Guryanta , continued first in Ozurgeti, then in Batumi , and finally in 1912 she graduated from Poti Gymnasium.

The theater was the passion of the Tsutsunava family. Cecilia, together with her younger brother, got interested in this field of art early on. She made his debut in Batumi, where she performed the role of Salikha in Nino Nakashidze's play "Who is to blame?".

She was forced to start teaching in the village of Tamish in Abkhazia , where a school was founded at that time. In 1920 , she moved to Tbilisi and joined the Rustaveli Theater until 1926, in 1926-1928 she was acting in the "Red Theater" of Tbilisi, And in 1928 in the State Academic Theater named after Kote Marjanishvili , where she served the Georgian theater until the end of his life. She portrayed: Karozhna ("Trouble of Darispan"), Maka ("Nut in the Heart"), Darejan ("Man is a man?!"), Anna Andreevna ("Revisor"), Marcelina ("Marriage of Figaro"), Lirsa ("Kvarkvara Tutaberi "), and many others.

Tsutsunava's creative work in Georgian cinema began in the 20s , although the audience saw her for the first time in the first Georgian feature film "Christine" shot in 1916 , where she created the memorable face of Marine. This was followed by excellent roles in other films: "Who's to blame", "Guli", "Eliso", "Late Bride", "Keto and Kote", "Dragonfly" and others.

Tsecilia Tsutsunava was a highly characterful and comedic actress of rich creative nature. Her contribution to the Georgian theater art was marked with an order and medals during the Red Time of Labor .

She is buried in the Didube pantheon of writers and public figures, Tbilisi .