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Michele Santopietro is an American actress of Sicilian and Italian descent. She is probably best known for her recurring character JoJo Palmice on HBO's critically acclaimed series The Sopranos, from seasons 1 through 4. Santopietro has also had guest appearances on television shows such as Law & Order, Law & Order SVU, Sex and the City, and the CBS television series New York News.

Santopietro also played one of the lead characters, Laura, in the Lionsgate feature film Two Family House with Michael Rispoli and Kelly MacDonald—a role they felt so strongly about casting her for that they actually "aged" her for camera. She also recently starred opposite Adrian Grenier in the feature film A Perfect Fit, and can be seen opposite Teri Polo and Barry Bostwick in the made for television film Love is a Four Letter Word.

Santopietro stars in The Donner Party (2009), where she stars alongside Crispin Glover, Christian Kane, Mark Boone Jr. and Clayne Crawford. The film is based on the historical Donner Party in 1846 and Santopietro plays Amanda McCutcheon, a courageous Southern woman who undergoes unspeakable tragedies on her journey in order to survive. She also voices the character Anabel in the Flash game Neverending Light.